This is one of the craziest designs yet -- a sort of cloth covered fold-out folio in which the contents are then inserted.  You'll have to see it for yourself to understand.  Here's what McSweeney's has to say:  "Issue 16 presents new stories from McSweeney's regulars like Roddy Doyle and Denis Johnson, and exploits a never-before-seen tripartite format to bring you a hilarious Ann Beattie novella and a special deck-of-cards story from Robert Coover, one of the great masters of American experimental fiction. This issue uses more cloth than any issue to date. Also, it comes with a comb."